Principles of Drug Action 1, Spring 2005, Aldehydes and Ketones

Boric Acid: As a Green Catalyst for the Conversion of Aldehydes and Ketones to Gem-Dihydroperoxides Using Aqueous 30% H2O2

Gem-dihydroperoxides as nearly stable peroxidic derivatives of aldehydes and ketones are known important intermediates in synthesis of anti-malaria drugs. Also, because containing high concentration of peroxidic oxygen, recently, some of these compounds have been used as solid, efficient and powerful oxidants in many oxidation organic reactions. Generally, these compounds are synthesiz...

[MoO2Cl2] as catalyst for hydrosilylation of aldehydes and ketones.

The high valent molybdenum-dioxo complex [MoO2Cl2] catalyzes the addition of dimethylphenylsilane to aldehydes and ketones to afford the corresponding dimethylphenylsilyl ethers in quantitative yield.

Direct asymmetric aldol-Tishchenko reaction of aliphatic ketones catalyzed by syn-aminoalcohol-Yb(III) complexes.

The asymmetric direct aldol condensation of aldehydes with ethyl- and propylketones is catalyzed by syn-alpha-aminoalcohol-Yb(OTf)3 complexes, yielding the anti-1,3-diol monoesters with high diastereocontrol and good enantioselectivity. Three adjacent stereogenic centers are created in a simultaneous aldol condensation and Evans-Tishchenko reduction in an acyclic system.

Melamine trisulfonic acid as an efficient and reusable catalyst for the crossed-Aldol condensation of ketones and aldehydes under solvent-free conditions

Various types of aldehydes undergo crossed-Aldol condensation with ketones in the presence of melamine trisulfonic acid (MTSA) under solvent-free conditions. The reported method is mild, efficient and has the advantages such as using heterogeneous catalysis, short reaction times, high yields of the products and the recyclability of the catalyst.

0587 A Mouse Aldo - keto Reductase Confers Resistance to Toxic Aldehydes and Ketones in vitro